DTB podcast

BMJ Group

For 50 years, Drug and Therapeutics Bulletin (DTB) has provided rigorous and independent evaluations of, and practical advice on, individual treatments and the overall management of disease for doctors, pharmacists and other healthcare professionals. DTB has always been wholly independent of the pharmaceutical industry, Government and regulatory authorities. DTB is also free of advertising and other forms of commercial sponsorship. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page - https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309. * The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

All Episodes

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) provide an overview of the December issue of DTB. They discuss a recently published national report on overprescribing of medicines. The editors talk about a study that assessed the accuracy of home blood pressure monitors (https://dtb.bmj.com/content/59/12/179) and highlight a safety alert on topical steroid withdrawal reactions (https://dtb.bmj.com/content/59/12/184). They also review an article on the US Food and Drug Administration's decision to license bremelanotide and flibanserin for 'hypoactive sexual desire disorder’ in women (https://dtb.bmj.com/content/59/12/185).

Nov 22

22 min 41 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) provide an overview of the November issue of DTB. They discuss a French initiative that identifies a range of drugs that should not be prescribed (https://dtb.bmj.com/content/59/11/162) and talk about the difficulty of assessing whether patients' penicillin allergy records are correct (https://dtb.bmj.com/content/59/11/163). They also review an article on the use of romosozumab for osteoporosis (https://dtb.bmj.com/content/59/11/169). They begin by highlighting DTB's blog for World Evidence-Based Healthcare Day (https://worldebhcday.org/) on the role of independent drug bulletins during an info-demic. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

Oct 24

19 min 56 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) provide an overview of the October issue of DTB. They discuss the impact of making desogestrel contraceptives available for purchase from pharmacies (https://dtb.bmj.com/content/59/10/146) and talk about the role of percutaneous coronary intervention in patients with stable ischaemic heart disease (https://dtb.bmj.com/content/59/10/150). They also review an article about managing migraine in pregnancy (https://dtb.bmj.com/content/59/10/152). They begin by highlighting the decision to remove pregabalin from the Northern Ireland formulary for neuropathic pain. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

Sep 29

21 min 49 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) provide an overview of the September issue of DTB. They discuss the US FDA's controversial decision to license aducanumab for Alzheimer's disease (https://dtb.bmj.com/content/59/9/130) and consider barriers to prescribing shorter courses of antibiotics in primary care (https://dtb.bmj.com/content/59/9/131). The editors also highlight the impact that some medicines have on oral health and dental treatment (https://dtb.bmj.com/content/59/9/135). Before all of that though, the recent NICE's guideline on shared decision making. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

Aug 23

23 min 51 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) provide an overview of the August issue of DTB (https://dtb.bmj.com/content/59/8). The editors talk about the MHRA's decision to reverse the EMA's decision and allow boron-containing chloramphenicol eye drops to be used in children aged below 2 years. They discuss a scheme in England that allows hospital staff to refer patients who would benefit from extra guidance around their medicines regimen for support from a community pharmacy (https://dtb.bmj.com/content/59/8/114). They also highlight the risk from concurrent opioid and benzodiazepine use (https://dtb.bmj.com/content/59/8/116), and talk about home blood pressure monitoring (https://dtb.bmj.com/content/59/8/119). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

Jul 26

20 min 56 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) provide an overview of the July issue of DTB. The editors catch up on developments with proposals for all doctors in the UK to provide financial and non-financial declarations of interest. They discuss the problem of boron in chloramphenicol eye drop products and the impact on treating children aged under 2 years (https://dtb.bmj.com/content/59/7/98). The editors also talk about PPIs for persistent throat symptoms (https://dtb.bmj.com/content/59/7/102), the dose of folic acid for use with methotrexate (https://dtb.bmj.com/content/59/7/103) and a case of a patient who developed severe hypophosphataemia with an oral bisphosphonate (https://dtb.bmj.com/content/59/7/107). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

Jun 23

26 min 46 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) review the June issue of DTB. The list of articles mentioned in this podcast: The Editorial “COVID-19 vaccination in pregnancy” - https://dtb.bmj.com/content/59/6/82 DTB select “Stepping down asthma treatment” - https://dtb.bmj.com/content/59/6/85 Review “Prescribing for pregnancy: managing diabetes” - https://dtb.bmj.com/content/59/6/88 Republished case report “Euglycaemic diabetic ketoacidosis in a 43-year-old woman with type 2 diabetes mellitus on SGLT-2 inhibitor (empagliflozin)” - https://dtb.bmj.com/content/59/6/93 Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

May 24

25 min 19 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) review the May issue of DTB. In light of the "First do no harm" report, the editorial discusses the need for a mandatory register of payments made by pharmaceutical and medical device companies to healthcare professionals, healthcare organisations and patient support organisations (https://dtb.bmj.com/content/59/5/66). The editors talk about the BTS guideline on long-term use of macrolides (https://dtb.bmj.com/content/59/5/67). The main article explores the use of CAR T-cell therapy (https://dtb.bmj.com/content/59/5/73) and the case report is of a patient who developed quinidine hypersensitivity (https://dtb.bmj.com/content/59/5/77). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

Apr 26

20 min 33 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) review the April issue of DTB. The editorial discusses variability in the management of people with severe asthma (https://dtb.bmj.com/content/59/4/50). The editors talk about a summary of an article on changes in prescribing of statins (https://dtb.bmj.com/content/59/4/53). The main article explores the use of aspirin for pre-eclampsia (https://dtb.bmj.com/content/59/4/56) and the case report is of a patient who developed omeprazole-induced hypomagnesaemia (https://dtb.bmj.com/content/59/4/60). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

Mar 22

27 min 1 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) review the March issue of DTB (https://dtb.bmj.com/content/59/3). The editorial discusses a national safety alert that highlighted the risk of dependence associated with prolonged use of opioids for non-cancer pain and a proposal that all opioid medicines in the UK carry the warning "can cause addiction" (https://dtb.bmj.com/content/59/3/34). The editors talk about an article on the rationale and science behind bisphosphonate holidays (https://dtb.bmj.com/content/59/3/35). The main article explores the risk of nitrosamine contamination in medicines (https://dtb.bmj.com/content/59/3/39) and the case report is of a patient who developed an unusually impressive atorvastatin-induced elevation of serum alkaline phosphatase (https://dtb.bmj.com/content/59/3/43). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Also, DTB is running a short survey to find out what people think of our content. Please visit https://dtb.bmj.com to find a link to the survey.

Feb 23

23 min 12 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) discuss the February issue of DTB. This includes an editorial that highlights the benefits associated with the human papillomavirus (HPV) and herpes zoster vaccination programmes (https://dtb.bmj.com/content/early/2021/01/11/dtb.2020.000048). The editors talk about a cohort study, which found that many older people who had recently been prescribed a calcium-channel blocker for hypertension were subsequently given a loop diuretic. The main article reviews the use of prescribing safety indicators to improve outcomes for patients and the case report is of a patient who developed immune checkpoint inhibitor-mediated large vessel vasculitis. Read the issue on the DTB website: https://dtb.bmj.com/content/59/2 Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

Jan 25

23 min 40 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) discuss the January issue of DTB (https://dtb.bmj.com/content/59/1). This includes an editorial that highlights the urgent need for more information for the public to support the national COVID-19 vaccination programme (https://dtb.bmj.com/content/59/1/2). The editors talk about the importance of knowing how patients use their medicines at home (https://dtb.bmj.com/content/59/1/3)and discuss advice for population vitamin D supplementation in adults in the UK (https://dtb.bmj.com/content/59/1/7). This month's case report involves two patients who developed severe hypothermia, bradycardia and cardiac arrest in association with risperidone (https://dtb.bmj.com/content/59/1/13). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening.

Jan 4

22 min

In this podcast James Cave (Editor in Chief) and David Phizackerley (Deputy Editor) discuss some of the challenges associated with the national COVID-19 vaccination programme. In particular, they highlight the importance of making information on the vaccines’ safety and efficacy available to help people make an informed decision on vaccination. Read the paper: https://dtb.bmj.com/content/early/2020/11/24/dtb.2020.000071 Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Go well and stay well.

Nov 2020

13 min 4 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) preview the December issue of DTB. This includes an editorial that discusses the results of a study that suggested that people who took antihypertensive medication at bedtime had a lower risk of a cardiovascular event. The editors talk about a threat to the supply of the Priadel brand of lithium carbonate. They also discuss the use of esketamine for treatment-resistant depression. This month's case report involves an unintentional overdose of hyoscine hydrobromide in a young child. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Go well and stay well.

Nov 2020

24 min 8 sec

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) preview the November issue of DTB. This includes an editorial that focuses on the National Institute of Health and Care Excellence's draft guideline on the management of chronic pain, and in particular, the approach to treating chronic primary pain (https://dtb.bmj.com/content/58/11/162). The editors talk about a new patient-held steroid emergency card that has been introduced to help healthcare staff identify adult patients with adrenal insufficiency (https://dtb.bmj.com/content/58/11/163). They also discuss the diagnosis and treatment of orthostatic hypotension. This month's case report involves a patient who developed medication-related osteonecrosis (MRONJ) of the mandible and maxilla (https://dtb.bmj.com/content/58/11/172). Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Go well and stay well.

Oct 2020

15 min 34 sec

A socially distanced podcast with James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) previewing the October issue of DTB. This includes an editorial that discusses the harms caused by medicines and medical devices and highlights concerns over proposals to speed up the UK licensing process for medicines. The editors talk about an article that looks at the influence of pharmaceutical marketing. They also review three new medicines used to prevent migraines. This month's case report involves a patient with rheumatoid arthritis who received latent tuberculosis infection treatment prior to treatment with a biologic agent, and developed shock with resistant hypotension on re-exposure to rifampicin. Read the full issue: https://dtb.bmj.com/content/58/10 Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Go well and stay well.

Sep 2020

21 min 2 sec

As we continue with our socially distanced DTB podcasts James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) provide an overview of the September issue of DTB. This includes an editorial discussing the challenges facing commissioning organisations when changes to clinical practice or market authorisation have a significant impact on how biological therapies can be used. The editors highlight a study that showed a lack of adherence to guidelines on direct oral anticoagulant dosing in people with atrial fibrillation and renal impairment, and review an article that discusses the risk of seizures with antidepressants. This month's case report involves an Infant with status epilepticus secondary to systemic lidocaine toxicity from topical application. Read the full issue: https://dtb.bmj.com/content/58/9 Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Go well and stay well.

Aug 2020

19 min 7 sec

Another socially distanced DTB podcast features James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) who provide an overview of the August issue of DTB. This includes an editorial discussing the changes that have taken place in general practices and the new ways of working that have been developed during the coronavirus pandemic (https://dtb.bmj.com/content/58/8/114). The main article reviews the evidence for using vitamin D and calcium in older people who have osteoporosis (https://dtb.bmj.com/content/58/8/122) and the case report highlights the problems faced by a young man who developed a hyperkinetic reaction to dihydrocodeine (https://dtb.bmj.com/content/58/8/126). Read the full issue: https://dtb.bmj.com/content/58/8. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Go well and stay well.

Jul 2020

19 min 28 sec

Another socially distanced DTB podcast features James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor), who provide an overview of the July issue of DTB. This includes an editorial that discusses some of the challenges in supplying low-dose aspirin to pregnant women for prevention of pre-eclampsia, a DTB Forum article by Margaret McCartney on some of the challenges to evidence-based medicine during the coronavirus pandemic and a DTB Select update on the safety of ibuprofen in people with COVID-19. The main article discusses managing antiepileptic drugs before and during pregnancy for women with epilepsy, and this month's case report is of amiodarone-induced diffuse alveolar haemorrhage. Read the full issue: https://dtb.bmj.com/content/58/7 Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Go well and stay well.

Jun 2020

18 min 39 sec

With the coronavirus pandemic restrictions still in place, this socially distanced DTB podcast features James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor), who provide an overview of the June issue of DTB. This includes an editorial that discusses whether clinicians should be deprescribing some medicines during the pandemic, and a summary of the EMA's advice on the use of drugs that affect the renin-angiotensin system in people who have COVID-19. The main article looks at the gastrointestinal risks of NSAIDs and the evidence for gastroprotection, and the issue finishes with a case report of drug reaction with eosinophilia and systemic symptoms syndrome in a patient taking lamotrigine. Please read the full issue: https://dtb.bmj.com/content/58/6. Subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Go well and stay well.

May 2020

21 min 35 sec

As the UK continues to be in lockdown because of the coronavirus pandemic, this podcast only features David Phizackerley, DTB's Deputy Editor, who provides a brief overview of the May issue of DTB. This includes an editorial that discusses the challenges facing clinicians in involving children and young people in decisions about their healthcare; a summary of the EMA's advice on the use of ibuprofen in people who have Covid-19; and an article on the development of shared care prescribing guidelines over the last 30 years. The main article looks at the benefits and harms of using potassium permanganate for wound care, and the issue finishes with a case report of hypersensitivity pneumonitis associated with sertraline. Please subscribe to the DTB podcast to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (podcasts.apple.com/gb/podcast/dtb-…ast/id307773309). Thank you for listening. Go well and stay well.

Apr 2020

4 min 52 sec

In April's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss lung volume reduction surgery for patients with emphysema-predominant COPD (https://dtb.bmj.com/content/58/4/50). They highlight the results of a trial of low-dose amitriptyline for chronic low back pain (https://dtb.bmj.com/content/58/4/53), discuss the use of depot triamcinolone injection for hay fever (https://dtb.bmj.com/content/58/4/57), and talk about a case in which dapagliflozin was thought to have caused euglycaemic diabetic ketoacidosis (https://dtb.bmj.com/content/58/4/60). If you enjoy the DTB podcast, please subscribe to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment on the DTB Podcast iTunes podcast page (https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309). Thank you for listening. Read the full April issue: dtb.bmj.com/content/58/4

Mar 2020

14 min 39 sec

In March's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the decision to extend the license for dapagliflozin 5 mg tablets to include use by people with type 1 diabetes and highlight concerns over the incidence of diabetic ketoacidosis. They review an article on managing asthma before and during pregnancy and talk about a case of partial nephrogenic diabetes insipidus associated with lithium therapy. Read the full March issue: dtb.bmj.com/content/58/3 If you enjoy the podcast, please subscribe to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment at https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309. Thank you for listening.

Feb 2020

10 min 9 sec

In February's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) consider the impact of conflicts of interest and highlight the need to establish comprehensive registers of conflicts of interest for healthcare professionals, healthcare providers and patient support groups. They briefly review an article on melatonin for jet lag (a longer version is available here: https://soundcloud.com/bmjpodcasts/melatonin-for-jet-lag?in=bmjpodcasts/sets/dtb-podcast), discuss a review of the management of nocturnal enuresis and highlight a report of a possible case of statin-induced delayed rhabdomyolysis. Read the full February issue: https://dtb.bmj.com/content/58/2 If you enjoy the podcast, please subscribe to get episodes automatically downloaded to your mobile device and computer. Also, please consider leaving us a review or a comment at https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309. Thank you for listening.

Jan 2020

10 min 4 sec

In this podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss a formulation of melatonin that has been licensed in the UK for the management of jet lag. The editors review the evidence for its effectiveness in reducing symptoms of jet lag and consider whether it should be available from the National Health Service. Read the article here: http://dx.doi.org/10.1136/dtb.2019.000074. Please subscribe to the DTB Podcast to get episodes automatically downloaded to your phone and computer every month. If you enjoy the show, please leave us a review or a comment at podcasts.apple.com/gb/podcast/dtb-…ast/id307773309. Thank you for listening!

Dec 2019

8 min 54 sec

In January's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) consider the burden of overprescribing and discuss how to tackle some of the barriers to deprescribing (https://dtb.bmj.com/content/58/1/2). They also review an article on the place of aspirin for primary prevention of cardiovascular disease (https://dtb.bmj.com/content/58/1/3), highlight an article on prescribing for pregnancy for women with mental health issues (https://dtb.bmj.com/content/58/1/8), and discuss a case report of sitagliptin-induced seronegative rheumatoid arthritis (https://dtb.bmj.com/content/58/1/12). Please subscribe to get episodes automatically downloaded to your phone and computer every month. If you enjoy the podcast, please leave us a review or a comment at https://podcasts.apple.com/gb/podcast/dtb-podcast/id307773309. Thank you for listening.

Dec 2019

10 min 8 sec

In December's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) consider the results of a recent study that assessed the effect of a combination pill containing aspirin, atorvastatin, enalapril and hydrochlorothiazide on major cardiovascular outcomes - https://dtb.bmj.com/content/57/12/178. The editors discuss prasterone, a newly introduced treatment for vulvar and vaginal atrophy - https://dtb.bmj.com/content/57/12/185. They also review a case report of retrograde ejaculation associated with quetiapine and treatment with low-dose imipramine - https://dtb.bmj.com/content/57/12/189. Read the December issue on the DTB website: https://dtb.bmj.com/content/57/12.

Nov 2019

10 min 28 sec

In November's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss whether primary care targets for managing blood pressure control in older people are achievable or desirable. The editors also introduce the first of a series of articles that consider therapeutic challenges when preparing for pregnancy and highlight some of the key issues that should be considered for all women as part of pre-pregnancy care. They also review a case report of apixaban-induced acute interstitial nephritis. Read the full November issue: https://dtb.bmj.com/content/57/11

Oct 2019

11 min 13 sec

In October's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss wide variation in the use of fibrates and the need for clinicians to consider whether their prescribing of fibrates is up to date and appropriate for their patients. The editors also talk about the evidence for fibrates in primary and secondary prevention of cardiovascular disease, highlight recent changes in the BNF and review a case of severe acute ocular hypertension following pulsed methylprednisolone. Read the full October issue: https://dtb.bmj.com/content/57/10

Sep 2019

8 min 39 sec

In September's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the roll out of social prescribing across the NHS in England. The editors also talk about a new formulation of naloxone for emergency treatment of opioid overdose in adults and review a case that involved successful thrombolysis for acute ischaemic stroke after using idarucizumab to reverse the action of dabigatran etexilate. To read any of the September articles, please visit: https://dtb.bmj.com/content/57/9.

Aug 2019

10 min 37 sec

In August's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss pre-eclampsia and the benefit of measuring the level of placental growth factor to help speed up diagnosis. The editors also talk about the challenge of communicating evidence to patients and review a case of complex encephalopathy arising from the combination of opioids and gabapentin. Read the full issue: https://dtb.bmj.com/content/57/8.

Jul 2019

5 min 48 sec

In July's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the work that patients have to do to manage their health and how this is not recognised by clinical guidelines. The editors also talk about the non-drug management of low back pain and discuss a case of metformin-associated lactic acidosis precipitated by liraglutide use. Read the full issue: dtb.bmj.com/content/57/7.

Jun 2019

7 min 19 sec

In June's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) consider the European Medicines Agency's decision to amend the licence for omega-3 fatty acid medicines so that they will no longer be authorised for secondary prevention after myocardial infarction. The editors also review ospemifene, a new medicine for the management of vulvar and vaginal atrophy and discuss a case of delusional infestation in the treatment of ADHD with atomoxetine. Read the full issue: https://dtb.bmj.com/content/57/6.

May 2019

9 min

In May's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) highlight some of the opportunities for drugs and therapeutics in the new GP contract for England. The editors also talk about the management of chronic cough and discuss a case of acute liver failure associated with a short course of nitrofuantoin. Read the issue online: https://dtb.bmj.com/content/57/5.

May 2019

8 min 33 sec

In April's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) highlight some of the challenges of prescribing direct acting oral anticoagulant (DOAC) drugs for people with renal impairment. The editors also talk about the use of saline nasal irrigation and discuss central sensitisation syndrome. Read the issue online: https://dtb.bmj.com/content/57/4.

Mar 2019

10 min 53 sec

In March's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) get excited about the impact that the results of the Direct study could have on the management of type 2 diabetes. The editors also discuss the combination of doxylamine and pyridoxine for the treatment of nausea and vomiting in pregnancy and consider the role of primary care in supporting patients who are taking clozapine. Read the full issue: https://dtb.bmj.com/content/57/3.

Feb 2019

13 min 48 sec

In February's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the use of inhaled corticosteroids in the management of COPD (https://dtb.bmj.com/content/57/2/18). The editors also consider subclinical hypothyroidism in pregnancy (https://dtb.bmj.com/content/57/2/22) and discuss Gilbert’s syndrome (https://dtb.bmj.com/content/57/2/27). Read the full issue: https://dtb.bmj.com/content/57/2

Jan 2019

8 min 48 sec

In January's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss whether intravenous antibiotics are always needed. The editors also consider the challenge of stopping antipsychotic drug treatment in people with intellectual disability and review a case of angioedema of the small bowel caused by lisinopril. Read the issue: dtb.bmj.com/content/57/1.

Dec 2018

9 min 36 sec

In December's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the conditional authorisation process for medicines and the need for clearer labelling of medicines that have been through this approval processes. The editors also consider common sources of information on medicines for patients and review a case of interstitial lung disease associated with adalimumab. Read the issue: https://dtb.bmj.com/content/56/12.

Nov 2018

7 min 43 sec

In November's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss a recent study that compared a coordinated, multi-professional, multi-faceted primary care approach to managing people with multiple long-term conditions with usual general practice care. The editors also consider problems faced by patients who need to travel overseas with controlled drugs and review a case of splenic rupture associated with rivaroxaban. Read the November issue: https://dtb.bmj.com/content/56/11.

Oct 2018

9 min 37 sec

In October's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the place of population screening for atrial fibrillation and the need for more evidence to support a change in national policy (https://dtb.bmj.com/content/56/10/112). The editors also consider problems associated with long-term opioid use in the management of chronic pain (https://dtb.bmj.com/content/56/10/118). Please watch the video about Michael's moving story on this subject at dtb.bmj.com. The launch of slidenafil as an over-the-counter pharmacy medicine (https://dtb.bmj.com/content/56/10/123) is also discussed. Read the latest from the reinvented Drug and Therapeutics Bulletin here: dtb.bmj.com.

Oct 2018

10 min 47 sec

In September's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) highlight some of the changes to DTB that have taken place this month and discuss the background and rationale to these changes. Read this month's editorial: https://dtb.bmj.com/content/56/9/98. The editors also consider the place for monitored dosage systems (https://dtb.bmj.com/content/56/9/102) and discuss the evidence for using labetalol as a first-line treatment option for hypertension in pregnancy (https://dtb.bmj.com/content/56/9/107). Meet the new DTB here: https://dtb.bmj.com/content/56/9.

Sep 2018

8 min 55 sec

In the August's podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the results of an awarding research paper that assessed the impact of spending the second stage of labour either in a recumbent or upright position. Read the editorial: https://dtb.bmj.com/content/56/8/85. The editors also consider nutritional support in primary care (https://dtb.bmj.com/content/56/8/90) and discuss new licensing pathways that provide faster access to medicines (https://dtb.bmj.com/content/56/8/93).

Aug 2018

11 min 13 sec

In July’s podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the risk of drug interactions with herbal medicines. Read the editorial: https://dtb.bmj.com/content/56/7/73. The editors also review the evidence for ocrelizumab for relapsing MS and early primary progressive MS (https://dtb.bmj.com/content/56/7/80), and discuss the role of metformin in people with type 1 diabetes (https://dtb.bmj.com/content/56/7/78).

Jul 2018

13 min 6 sec

In the June’s podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss whether a recently published large meta-analysis on the effectiveness of antidepressants tells us anything new. Read the editorial here: dtb.bmj.com/content/56/6/61. The editors also review the evidence for the combination analgesic of tramadol/dexketoprofen (dtb.bmj.com/content/56/6/66), and question the dose of paracetamol for older people (dtb.bmj.com/content/56/6/69).

Jul 2018

10 min 52 sec

In this month’s podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the evidence for pulmonary rehabilitation for COPD and highlight the need for more publicity for its benefits. Read the editorial here: http://dtb.bmj.com/content/56/5/49. The editors also review the evidence for safinamide for Parkinson’s disease (http://dtb.bmj.com/content/56/5/54), and discuss the use of bezlotoxumab, a monoclonal antibody licensed for the prevention of recurrence of Clostridium difficile infection in adults who are at high risk of recurrence (http://dtb.bmj.com/content/56/5/57).

May 2018

11 min 59 sec

In this month’s podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss a national campaign in England that is tackling the inappropriate use of antipsychotic and antidepressant medicines in people with learning or intellectual disability. Read the article: http://dtb.bmj.com/content/56/4/37. The editors also review the evidence for a once-daily triple inhaler for maintenance treatment for adults with moderate to severe COPD (http://dtb.bmj.com/content/56/4/42), and discuss off-label use of high-dose antihistamines for chronic spontaneous urticaria in adults (http://dtb.bmj.com/content/56/4/45).

Apr 2018

15 min 33 sec

In this month’s podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss some of the difficulties in implementing clinical guidelines for the management of elevated blood pressure and the potential impact of changes in the threshold for a diagnosis of hypertension (http://dtb.bmj.com/content/56/3/25). The editors also review the evidence for dupliumab for the treatment of moderate-to-severe atopic dermatitis in adults (http://dtb.bmj.com/content/56/3/30) and discuss drug names (http://dtb.bmj.com/content/56/3/33). Read the full March 2018 issue here: http://dtb.bmj.com/content/56/3.

Mar 2018

11 min 15 sec

In this month’s podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the importance of developing patient decision aids to support the implementation of clinical guidelines (http://dtb.bmj.com/content/56/2/13). The editors also review the evidence for cladribine for the treatment of highly active relapsing multiple sclerosis (http://dtb.bmj.com/content/56/2/21) and discuss the latest levonorgestrel IUS device to be marketed for contraception (http://dtb.bmj.com/content/56/2/18).

Feb 2018

13 min 10 sec

In this month’s podcast, James Cave (DTB Editor-in-Chief) and David Phizackerley (DTB Deputy Editor) discuss the importance of exercise, diet and behaviour modification in the management of obesity and consider the limitations of anti-obesity drugs. http://dtb.bmj.com/content/56/1/1 The editors also review the evidence for ▼patiromer, a cation exchange polymer, that has recently been marketed for the management of hyperkalaemia - http://dtb.bmj.com/content/56/1/6 and discuss the management of gout. http://dtb.bmj.com/content/56/1/9

Jan 2018

12 min 36 sec