Gut podcast

BMJ Group

Gut is a leading international journal in gastroenterology and hepatology. It has an established reputation for publishing first class clinical research of the alimentary tract, the liver, biliary tree and pancreas. Gut delivers up-to-date, authoritative, clinically oriented coverage of all areas in gastroenterology. Regular features include articles by leading authorities, reports on the latest treatments for diseases, reviews and commentaries. Subscribers to Gut also receive Frontline Gastroenterology (FG).

The Gut Podcast discusses highlights from its issues monthly. Please subscribe in all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify. * The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others.

All Episodes

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Professor Andrew Chan, Harvard Medical School, Boston, USA. This podcast is focused on the paper "Diet quality and risk and severity of COVID-19: a prospective cohort study", published in paper copy in Gut in November 2021. Link to the paper: https://gut.bmj.com/content/70/11/2096

Oct 29

7 min 25 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Professor Megraud, University of Bordeaux, France. The podcast is focused on the paper "Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community”, which is published in paper copy in Gut in October 2021. Link to the paper: https://gut.bmj.com/content/70/10/1815

Oct 1

6 min 32 sec

In this podcast, we'll explore how eating a ‘blue’ muffin is an inexpensive and scalable technique allowing the measurement of transit time. The method was used to assess the relationship between gut transit time and the human gut microbiome, in a study published in paper copy in Gut, in September 2021. "Blue poo: impact of gut transit time on the gut microbiome using a novel marker" is accessible here: https://gut.bmj.com/content/70/9/1665 Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Dr Sarah Berry, Department of Nutritional Sciences, King's College London, London. The Gut Podcast discusses highlights from its issues monthly. Please subscribe in all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify.

Sep 8

10 min 30 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Laura Bolte dietitian and PhD student from the Department of Gastroenterology and Hepatology and the Department of Genetics, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands and Professor Rinse Weersma from the Department of Gastroenterology and Hepatology at the University of Groningen and University Medical Centre Groningen, The Netherlands. The Gut podcast is focussed on the paper "Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome" which is published in paper copy in Gut in July 2021. Related or relevant article: https://gut.bmj.com/content/70/7/1287

Jul 1

14 min 46 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Gunnar C. Hansson from the Mucin Biology Groups, Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Sweden. The Gut podcast is focussed on the paper "Association between Brachyspira and irritable bowel syndrome with diarrhoea" which is published in paper copy in Gut in June 2021. Related or relevant article: https://gut.bmj.com/content/70/6/1117

Jun 1

13 min 6 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Dr Ryan Ungaro, who is an Assistant Professor at Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA. The podcast is focussed on ‘Effect of IBD medications on COVID-19 outcomes: results from an international registry’ published in paper copy in Gut in April 2021. Related or relevant article: https://gut.bmj.com/content/70/4/725

May 12

13 min 33 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Dr Tariq Ahmad and Dr Nick Kennedy, both from the Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, UK. This special Gut podcast is focused on ‘Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab’ which is published in paper copy in Gut in May 2021 and the recently published paper ‘Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines’. Acknowledgements: The CLARITY IBD team would like to thank the CLARITY IBD team in Exeter, all of the 92 CLARITY IBD sites and over 7000 participants in the study. We are grateful to support from the NIHR CRN, Crohn's & Colitis UK and our funders. The related links: https://gut.bmj.com/content/early/2021/04/25/gutjnl-2021-324789 https://gut.bmj.com/content/70/5/865

Apr 23

19 min 32 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Dr Fabian Frost who is a clinical scientist, internal medicine specialist and gastroenterologist in training working at the Department of Medicine A, University Medicine Greifswald, Germany. The podcast is focussed on ‘Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function’, published in paper copy in Gut, in March 2021. Link to the paper: https://gut.bmj.com/content/70/3/522.

Apr 6

13 min 26 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, UK, interviews Professor Nathanson, the Gladys Phillips Crofoot Professor of Medicine and Cell Biology at Yale University and the Director of the Yale Liver Center, Yale University School of Medicine, New Haven, Connecticut, USA. The podcast is focussed on "Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis", published in paper copy in Gut, in February 2021. Read it on the Gut website: http://dx.doi.org/10.1136/gutjnl-2020-322540

Mar 10

11 min 17 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, UK, interviews Professor Jyh-Ming Liou, Professor of Gastroenterology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. The podcast is focussed on "Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus" published in paper copy in Gut in December 2020. Read the related article: https://gut.bmj.com/content/69/12/2093

Feb 1

12 min 43 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, UK, interviews Professor Gisbert from the Gastroenterology Department, University Hospital of La Princesa, Madrid, Spain. The podcast is focused on "European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients" published in paper copy in Gut in January 2021, and online, here: https://gut.bmj.com/content/70/1/40

Jan 9

7 min

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, UK, interviews Professor Delzenne, President of the Louvain Drug Research Institute, at the UCLouvain, Brussels, Belgium. The podcast is focused on "Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients" published in paper copy in Gut in November 2020, and online at: https://gut.bmj.com/content/69/11/1975

Nov 2020

11 min 45 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Dr Rima Chakaroun who is a Clinician Scientist, Resident physician at the University Hospital in Leipzig, Germany, specialising in Endocrinology and Metabolic disease and a postdoctoral researcher and clinical investigator working on microbiome signatures in obesity in gut and beyond. The podcast is focused on "Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes" published in paper copy in Gut in October 2020. https://gut.bmj.com/content/69/10/1796

Oct 2020

19 min 20 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Dr Melina Arnold from the Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France. The podcast is focussed on "Global burden of oesophageal and gastric cancer by histology and subsite in 2018" published in paper copy in Gut in September 2020 https://gut.bmj.com/content/69/9/1564

Sep 2020

8 min 52 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Silvia Sookoian, who is Head of the Department of Clinical & Molecular Hepatology and Vice-Chair of Institute of Medical Research, at the Institute of Medical Research, Strategic Alliance between the National Scientific and Technical Research Council (CONICET)and the School of Medicine, University of Buenos Aires, Argentina; and Principal Investigator of the National Scientific and Technical Research Council. The podcast is focussed on "Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease" published in paper copy in Gut in August 2020. Link to the article: https://gut.bmj.com/content/69/8/1483

Aug 2020

13 min 2 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Madgy El-Salhy, who is a Professor of Gastroenterology at Bergen University and Consultant Gastroenterologist at Stord Hospital, Norway, on the paper ‘Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study’ published in paper copy in Gut in May 2020 - https://gut.bmj.com/content/69/5/859

Jul 2020

13 min 27 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Inga Peter, who is a Professor in the Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, on "Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice" published in paper copy in Gut in January 2020. Link to the paper: https://gut.bmj.com/content/69/1/42

Jun 2020

8 min 2 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Paul O'Toole; who is Professor of Microbial Genomics, Head of School of Microbiology and Principal Investigator in APC Microbiome Ireland, an SFI funded centre at University College Cork, Ireland, on "Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across 5 European countries" published in paper copy in Gut in July 2020 https://gut.bmj.com/content/69/7/1218

May 2020

14 min 54 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Professor Jacques Bergman who is Professor of Gastrointestinal Endoscopy at the Amsterdam University Medical Center, Amsterdam on "Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study" published in paper copy in Gut in February 2020. Accessible online here: https://gut.bmj.com/content/69/2/295

May 2020

12 min 17 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Dr Cathryn Edwards, BSG President and Consultant Gastroenterologist at Torbay Hospital, Devon and Dr Nick Kennedy, Consultant Gastroenterologist, Royal Devon and Exeter NHS Foundation Trust on the British Society of Gastroenterology response to the coronavirus pandemic and on the guidance produced by a team of UK IBD Specialists entitled ‘BSG guidance for management of IBD during the COVID-19 pandemic’ to be published in paper copy in Gut in June 2020. Paper link is: http://dx.doi.org/10.1136/gutjnl-2020-321244 Acknowledgements - BSG Risk stratification Grid for IBD patients on Immunosuppression - huge thanks go to: - Prof Charlie Lees, BSG Clinical Research Group (CRG) Chair and Lead of the UK IBD COVID-19 working group. Dr Ian Arnott BSG IBD Section Lead. Dr Chris Lamb, Dr Barney Hawthorne, BSG Guidelines Development Group (GDG) 2019, Dr Gareth Jones and Dr Nick Kennedy (IBD GDG and CRG) and 70+ clinical colleagues who contributed to the collaborative discussions through the COVID -19 working group - The BSG, in particular Dr Cathryn Edwards, the BSG Executive team and BSG Staff - The IBD Registry Group: Dr Stuart Bloom and Liz Dobson and AIMES who delivered the technical aspects of the IBD Registry web tool - The Crohn's & Colitis UK team particularly Rukshana Kapasi BSPGHAN, particularly Prof Richard Russell, Dr Richard Hansen BSPGHAN President Sue Protheroe and Prof Mark Beattie, Editor of Frontline Gastroenterology - Donal Donoghue Registrar RCP London and Medical Specialty Colleagues The many patients whose feedback helped improve the IBD Registry COVID-19 tool and the BSG guidance - The RCN

Apr 2020

23 min 7 sec

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Ms Rebecca Siegel, Scientific Director of Surveillance Research at the American Cancer Society. Ms Rebecca Siegel is first author on the paper 'Global patterns and trends in colorectal cancer incidence in young adults' published in Gut in December 2019. Read the article - https://gut.bmj.com/content/68/12/2179

Mar 2020

6 min 27 sec

Dr Christopher Lamb, Clinical Intermediate Fellow at Newcastle University and Honorary Consultant in Gastroenterology at the Newcastle upon Tyne Hospitals NHS Foundation Trust discusses the BSG guidelines on the management of inflammatory bowel disease in adults with Associate Editor of GUT Dr Philip Smith. Read the article: https://gut.bmj.com/content/68/Suppl_3/s1

Nov 2019

9 min 28 sec

Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. The guideline discussed in this podcast is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Marco del Chiaro, from The European Study Group on Cystic Tumours of the Pancreas. And read the details of the guidelines on the Gut website: https://gut.bmj.com/content/67/5/789.

Aug 2018

13 min 27 sec

Clostridium difficile (C. difficile, C. diff or CDI) is a bacterium associated with the intake of antibiotics which causes diarrhoea. It is easily spread to others, both in hospital and a household environments. C. Diff infections are generally treated with antibiotics. Recurrent infection is successfully treated with faecal microbiota transplantation (FMT), however the underlying mechanism of action is not well defined. This study identified a key role of the virome within the transferred stool on treatment responses. Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Siew Ng (The Chinese University of Hong Kong, China), who's the leading author of the Open Access paper “Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome”, included in the April 2018’s Gut issue (gut.bmj.com/content/67/4/634).

May 2018

17 min 36 sec

Prioritising research and funding could have a significant impact on reducing colorectal cancer disease burden over the next 5 years. The conclusions are included in a study recently published by Gut titled “Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer” and expanded in this podcast. In conversation with the journal’s Education Editor Mairi McLean, the leading author of the study, Mark Lawler, identifies 15 critical research gaps which prioritisation and resolution could improve patient outcomes. Professor Mark Lawler works at the Centre for Cancer Research and Cell Biology, Queen’s University Belfast, UK. For more details on this Open Access article included in the January 2018 issue of Gut, visit http://gut.bmj.com/content/67/1/179.

Mar 2018

19 min 42 sec

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Matias Avila and Carmen Berasai, University of Navarra, Pamplona, Spain. They discuss their published paper "Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration". Full article >> http://gut.bmj.com/content/66/10/1818.info

Nov 2017

23 min 53 sec

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Fergus Shanahan, Professor and Chair of the Department of Medicine at University College Cork. They discuss his recent paper in Gut entitled "Feeding the microbiota: transducer of nutrient signals for the host" Full text - http://gut.bmj.com/content/early/2017/06/29/gutjnl-2017-313872

Oct 2017

23 min 52 sec

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Benoit Chassaing, Georgia State University - Center for Inflammation, Immunity and Infection, about his recently published paper "Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation". Full paper>> http://gut.bmj.com/content/66/8/1414

Aug 2017

17 min 5 sec

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Giovanni Cammarota and Gianluca Ianiro from the Agostino Gemelli University. They discuss the April editors choice paper "European consensus conference on faecal microbiota transplantation in clinical practice". Full paper >> http://gut.bmj.com/content/early/2017/01/13/gutjnl-2016-313017

Jun 2017

17 min 56 sec

In this episode Mairi McLean, Education Editor for Gut, talks to Dr Katja Breitkopf-Heinlein, Medical Faculty Mannheim, Heidelberg University, about her recently published paper "BMP-9 interferes with liver regeneration and promotes liver fibrosis". Full paper >> http://gut.bmj.com/content/66/5/939

May 2017

16 min 48 sec

In this podcast Mairi McLean talks to Professor Jon Rhodes about his recently published paper "Recent advances in clinical practice: a systematic review of isolated colonic Crohn's disease: the third IBD?" Full paper >> http://gut.bmj.com/content/66/2/362

Feb 2017

17 min 4 sec

In this episode Mairi McLean talks to Herbert Tilg about his recently published paper "Gut microbiome and liver diseases". Full paper >> http://gut.bmj.com/content/65/12/2035.long

Feb 2017

24 min 40 sec

In this podcast Mairi McLean interviews Dr Gianluca Ianiro about the editors choice paper "Antibiotics as deep modulators of gut microbiota: between good and evil." Full paper >> http://gut.bmj.com/content/65/11/1906.full?sid=4929814b-b6f1-43d2-9af1-964357aa664c

Jan 2017

17 min 23 sec

In this episode Mairi McLean talks to Professor Fock about his recently published paper; "Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux disease and Barrett's oesophagus" Full paper >> http://gut.bmj.com/content/65/9/1402.full?sid=13ba6d1c-8c84-4ae9-9cd3-0bab0fa2b3a9

Oct 2016

23 min 15 sec

In this track Mairi McLean talks to Hasim El-Serag about the recent paper "Surveillance endoscopy is associated with improved outcomes of oesophagealadenocarcinoma detected in patients with Barrett's oesophagus."

Sep 2016

27 min 17 sec

In this podcast Dr Mairi McLean talks to Dr Sonia Friedman about the May editors choice paper "Live birth and adverse birth outcomes in women with ulcerative colitis and Crohn's disease receiving assisted reproduction: a 20-year nationwide cohort study". Full text > http://gut.bmj.com/content/65/5/767.full

Jun 2016

13 min 1 sec

In this podcast Dr Mairi McLean talks to Dr Mark Smits and Dr Djuna Cahen about their editors choice paper "GLP-1 based therapies: clinical implications for gastroenterologists"

May 2016

22 min 51 sec

In this podcast Dr Mairi McLean talks to Professor Dirk Haller about his editors choice paper "Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence." Read the full paper >> http://gut.bmj.com/content/65/2/225.full

Mar 2016

15 min 37 sec

In this podcast Dr Mairi McLean talks to Dr Christoph Gasche about his editors choice paper "Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2loxP/loxP Villin-Cre mice." Full paper >> http://gut.bmj.com/content/64/12/1905.full

Mar 2016

19 min 5 sec

In this podcast Dr Mairi McLean talks to Dr Joanna Jalanka about her recently published article in Gut entitled "Effects of bowel cleansing on the intestinal microbiota". They discuss what was already known in the field and what has since been discovered, and how long these effects last and how the microbiota were measured.

Jan 2016

11 min 10 sec

Mairi McLean talks to Thaddeus S Stappenbeck, Department of Pathology and Immunology, Washington University School of Medicine, about his paper: Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Read the full paper: http://goo.gl/xeWDHz

Aug 2015

22 min 10 sec

Helicobacter pylori strains that express the a protein that increases the risk of gastric cancer. However, the precise mechanisms through which the cancer risk is heightened have not been fully investigated and understood. In this podcast Dr Mairi McLean talks to Dr Lydia Wroblewski from the Vanderbilt University School of Medicine about the study her group conducted to define mechanisms through which H. pylori modulates expression of the cancer-associated tight junction protein claudin-7. To read the full paper please visit http://gut.bmj.com/content/64/5/720.full

Jun 2015

14 min 8 sec

Acute renal failure (ARF) is a common complication in patients with decompensated cirrhosis. The traditional diagnostic criteria of renal failure in these patients were proposed in 1996 and have been refined in subsequent years. More recently the International Club of Ascites (ICA)redefined the criteria to reach a new definition of acute kidney injury (AKI) in patients with cirrhosis. Dr Mairi McLean speaks to lead author Professor Paolo Angeli from the University of Padova about the scientific evidence supporting the new approach to the diagnosis and treatment of acute kidney injury.Read the full article >> http://gut.bmj.com/content/64/4/531.full

May 2015

13 min 15 sec

Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. Dr Mairi McLean speaks to Dr Toshikazu Ushijima about his study investigating these defects and the association with gastric cancer.

Apr 2015

16 min 10 sec

The genetic basis of inflammatory bowel disease (IBD) is incompletely understood, and the aim of a recent study in Gut was to identify rare genetic variants involved in the pathogenesis of IBD. Mairi McLean speaks to authors Sebastian Zeissig, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, and Andre Franke, Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, to hear what they found. Read the full paper: http://gut.bmj.com/content/64/1/66.full

Feb 2015

27 min 33 sec

The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. Now a paper in Gut has examined in detail the distribution of the full range of cell lineages within the human stomach. Mairi McLean talks to authors James Goldenring, Eunyoung Choi and Joseph Roland, all Vanderbilt University School of Medicine, Nashville, Tennessee. Read the full paper: http://gut.bmj.com/content/63/11/1711.full

Jan 2015

14 min 25 sec

Mairi McLean talks to Krisztina Gecse about the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease. Read the related article: http://gut.bmj.com/content/63/9/1381.full

Oct 2014

20 min 27 sec

The identification of a distinct syndrome, designated eosinophilic oesophagitis (EoE), with its own clinical and histopathological characteristics, was first described in the early 1990s. Meanwhile intense research has uncovered many molecular, immunological and clinical aspects of this chronic-inflammatory disorder. In this podcast, Mairi McLean talks to Professor Alex Straumann, Swiss EoE Clinic and EoE Research Network, about the basic and clinical insights of EoE gathered during the last few years. Read Professor Straumann's update on the topic: http://goo.gl/0B6h14

Sep 2014

25 min 38 sec

Inflammatory bowel disease is driven by a seemingly aberrant immune response to the gut microbiota with disease development dictated by genetics and environmental factors. A model exemplifying this notion is work by Andrew Gewirtz, Center for Inflammation, Immunity, & Infection, Georgia State University, and colleagues, demonstrating that colonisation of adherent-invasive Escherichia coli (AIEC) during microbiota acquisition drove chronic colitis in mice lacking the flagellin receptor TLR5 (T5KO). They have now published a paper in Gut hypothesising that AIEC instigates chronic inflammation by increasing microbial lipopolysaccharide and flagellin levels, and investigating how AIEC colonisation might instigate colitis in T5KO mice. Mairi McLean talks to Dr Gerwitz about their findings. Read the full paper (for free): http://gut.bmj.com/content/63/7/1069.full

Aug 2014

15 min 44 sec

Despite the success of hepatitis B virus vaccination in preventing new infection in endemic areas, chronic hepatitis B still poses a heavy burden globally. There are approximately 350 million carriers in the world, with an estimated 60 000 persons dying annually of hepatitis B-related cirrhosis and hepatocellular carcinoma. In a study recent published in Gut, Professor Man-Fung Yuen, Department of Medicine, The University of Hong Kong, and colleagues, report the results of viral suppression and safety of two doses of besifovir, with entecavir as a comparator in treatment-naive subjects for 48 weeks. He talks to Mairi McLean about the findings. Read the full paper: Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B http://gut.bmj.com/content/63/6/996.full

Aug 2014

9 min 29 sec