Advancing the Diagnosis and Treatment of Ductal Carcinoma in Situ (DCIS)

By Peter Hofland, Ph.D

In this edition of The Onco’Zine Brief Peter Hofland, Ph.D. talks with Leonard Farber, MD, a board-certified Radiation Oncologist, and healthcare executive. Farber is recognized for his ability to identify ground-breaking technologies and position them for success in clinical practice. He recently joined EHMET Health, an emerging medical device company with a state-of-the-art device for providing radiation as a treatment for breast cancer, Farber joined the company as the Chief Medical Officer and Executive Vice President of Clinical Research. Farber also works with a large number of pioneering startups focusing on health and medicine, including establishments such as PreludeDx.In today’s program, Hofland and Farber talk about Ductal Carcinoma in Situ or DCIS and DCISionRT, the only risk assessment test for patients with this disease, that predicts radiation therapy benefit.Ductal Carcinoma in SituIn the US, over 60,000 women are newly diagnosed with ductal carcinoma in situ or DCIS each year, accounting for an estimated 18 – 25% of the total number of newly diagnosed breast tumors. Fortunately, DCIS is a highly curable disease with a 10-year cancer-specific survival of about 97%. Because DCIS is a "forerunner" of invasive breast cancer – and is often referred to as a pre-cancer - early diagnosis and treatment are crucial for reducing the risk of developing invasive breast cancer. Current treatment strategies include breast-conserving surgery with radiotherapy, breast-conserving surgery alone, mastectomy or observation. A recent study demonstrated that 53% of DCIS patients' risk scores were under classified and 34% were overclassified using traditional methods, resulting in overtreatment or undertreatment.About The Onco'Zine BriefThe Onco'Zine Brief is distributed in the United States via PRX (Public Radio Exchange). In the United Kingdom and Europe, the program is distributed via UK Health Radio (UKHR). And the program can be downloaded via most podcasts and streaming media services, including iTunes, Spotify, TuneIn, and iHeart Radio.For more information about The Onco'Zine Brief or how to sponsor or support this public radio broadcast and podcast, visit: https://www.patreon.com/theoncozinebriefFor more information about cancer and cancer treatments, visit our online journal Onco'Zine at www.oncozine.comTo sign up for The Onco'Zine Newsletter (open for residents of the United States only), text the word CANCER to 66866.

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