Raised by progressive Telugu physician parents, he earned a B.A. in comparative politics and a master's degree in human rights studies. Kondabolu applied these degrees on two fronts: first as an immigrant organizer in Seattle, and then by appearing on television shows like Jimmy Kimmel Live and Live at Gotham. In 2011 he landed his first half-hour Comedy Central Presents television special, which was the same year that he and Dap launched The Untitled Kondabolu Brothers Project, an improvised talk show performed live in Brooklyn. The project became a podcast a year later, and in 2014 Kondabolu made his comedy album debut with Waiting for 2042, released by the Kill Rock Stars label. In 2016 he returned with Mainstream American Comic, an album that featured "mainstream" material such as "A Vegan Long Con," "Hilary, Bernie, and the Illuminati," and "White People Don't Like Being Called White People." The set peaked at number two on the Billboard comedy chart.
In 2017, Kondabolu released his documentary The Problem with Apu, about the stereotyped convenience store owner from The Simpsons. The following year, he starred in his own standup special, Warn Your Relatives. ~ David Jeffries & Neil Z. Yeung, Rovi