Born in a small town near Paris in 1986, Tixier grew up in an artistic family with a mother who is a dance teacher and pianist, a father who is an actor. His twin brother, Tony Tixier who is a jazz pianist. Tixier began taking violin lessons at age five.
Grammy Award winning bassist Marcus Miller says that Tixier "has made an international name for himself. I heard him in France and was immediately struck by his individuality and his sound." Guitarist Pat Metheny says, "[Scott] has found a place for himself within the elite community of New York jazz musicians, no small feat." In an interview with Jazz Mag, violinist Mark Feldman called Scott "really up-and-coming and very talented." Jean-Luc Ponty said "I have heard Scott's recordings, seen his live performances and I think that he stands above the crowd of current jazz violinists around the world."