In 2006, Holcomb married Ellie Bannister, a songwriter and musician he met when they they were both attending the University of Tennessee, and the newly renamed Ellie Holcomb began performing with Drew, joining in on guitar and vocals. With the addition of guitarist/keyboardist Nathan Dugger and bassist Rich Brinsfield, the act became known as Drew Holcomb & the Neighbors, and the band made its recording debut with a seasonal offering, A Neighborly Christmas (their first release for Magnolia Records), which appeared in late 2007, followed in mid-2008 with the album Passenger Seat. A Million Miles Away arrived in August 2009, and 2011's Chasing Someday became Holcomb & the Neighbors' first album to crack the Billboard Top 200 albums chart, peaking at 183. (It rose to eight on the folk chart and three on the independent survey.)

In 2012, Holcomb dropped another live album, Through the Night: Live in the Studio, and returned in early 2013 with Good Light, which climbed to 84 on the Top 200. By the time Holcomb & the Neighbors released Medicine in 2015, Ellie Holcomb had left the group to focus on her solo career (though she and Drew were still married), and Jon Radford joined on drums. The album continued the group's rising chart success, topping out at number 47 on the Top 200. In August 2016, Holcomb and the band unveiled Live at the Ryman, a live album recorded during their first appearance at Nashville's legendary Ryman Auditorium, the original home of the Grand Ole Opry. A brand-new studio album, Souvenir, was released in 2017, preceded by the politically charged first single, "Fight for Love." ~ Mark Deming