By 1967 he had relocated to San Francisco, and in 1969 released his seminal LP Boz Scaggs, recorded in Muscle Shoals, AL for Atlantic Records. Scaggs has continued to mine a personalized mix of rock, blues and R&B influences, along with a signature style of ballads.
1976’s Silk Degrees became a massive commercial breakthrough, reaching Number Two and remaining on the album charts for 115 weeks. It spawned three Top 40 hit singles: "It's Over," "Lido Shuffle" and the Grammy-winning "Lowdown." Subsequently, "We're All Alone” from that same album, would become a #1 single for Rita Coolidge. Silk Degrees was followed by the albums Down Two Then Left and Middle Man, and such hit singles as "Breakdown Dead Ahead," "Jo Jo" and "Look What You've Done to Me."
His critically acclaimed last album, Out Of The Blues, part of a trilogy with 2013’s Memphis and 2015's A Fool To Care, spent 8 weeks at #1 on the Billboard Blues Chart and was nominated for a 2018 Grammy award for Best Contemporary Blues Album.