In November of 2009, opened a YouTube channel and gained a number of followers from all over the world.
In 2011, Diane released her debut album, “Fly Away” with her song compositions and collaborations. It features her work with musicians and composers from London to Australia to US.
In 2013, Diane released her 2nd album, “Heartstrings”, an acoustic album featuring her heartfelt touch and rendition of her favorite love songs.
In 2014, Diane became the lead vocalist for the acoustic band, "Diane de Mesa and the LSS Sessionists" together with her bandmates.
In 2016, Diane released her 3rd album, "Only for you" that features her original collaborations with her band, and other talented and seasoned musicians.
Diane became the winner for the "Female Artist of the Year 2015" category nominated for by Star Central Magazine (based in Australia).
Some of Diane's singing clips have been featured in various TV shows in the Philippines, ABS-CBN/TFC shows such as ASAP and TV Patrol. She is consistently ranked #1 in the Reverbnation Local San Jose Singer-Songwriter pop charts.